Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 9/20 | 0.41 |
| ▸ | GIPR | P48546 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653130 | 0.92 | RAB9A (0.42) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR | |
| SCHEMBL2654108 | 0.86 | GCGR (0.52) | GCGRGIPR | |
| SCHEMBL2654464 | 0.84 | RXRA (0.51) | RAB9ANPC1PPARGPPARARXRA | |
| SCHEMBL2654365 | 0.84 | GCGR (0.44) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR | |
| SCHEMBL2653226 | 0.82 | GCGR (0.41) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR | |
| SCHEMBL2667193 | 0.81 | GCGR (0.44) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR | |
| SCHEMBL12648905 | 0.81 | GCGR (0.44) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR | |
| SCHEMBL1765931 | 0.81 | GCGR (0.44) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR | |
| SCHEMBL2656103 | 0.81 | GCGR (0.43) | GCGRGIPRPPARGPPARAGLP1R | |
| SCHEMBL12595569 | 0.78 | GCGR (0.51) | RAB9ASMN1; SMN2ALDH1A1NPC1GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |