Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13033293 | 0.86 | PPARA (0.46) | PTGER1CYP2C9L3MBTL1PPARAGRIN2B | |
| SCHEMBL25257191 | 0.76 | SYK (0.42) | PTGER1CYP2C9L3MBTL1SYKMEN1 | |
| SCHEMBL2644395 | 0.75 | PPARA (0.48) | PTGER1CYP2C9L3MBTL1PPARAGRIN2B | |
| SCHEMBL10515590 | 0.75 | PTGER1 (0.54) | PTGER1CYP2C9PPARAGRIN2BBRD4 | |
| SCHEMBL5089580 | 0.74 | PPARA (0.46) | L3MBTL1PPARABCHECNR2 | |
| SCHEMBL2644832 | 0.74 | HTR1A (0.44) | L3MBTL1MEN1KMT2A | |
| SCHEMBL32665616 | 0.73 | PTGER1 (0.46) | PTGER1CYP2C9L3MBTL1PPARABRD4 | |
| SCHEMBL2645197 | 0.72 | GSK3B (0.38) | GRIN2BSYK | |
| SCHEMBL3512263 | 0.71 | CXCR2 (0.42) | CXCR2SGMS2MEN1PABPC1KMT2A | |
| SCHEMBL12579812 | 0.71 | GCK (0.46) | PTGER1CYP2C9GRIN2BMEN1PABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572670-A1 | 5-SUBSTITUTED-PYRAZINE OR -PYRIDINE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004052869-A1 | 5-SUBSTITUTED-PYRAZINE OR PYRIDINE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-24 | — | — | WO | disclosed |