Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191550 | 0.84 | ATM (0.55) | PPARACTSSATMCTSKPTPN1 | |
| SCHEMBL191549 | 0.84 | ATM (0.55) | PPARACTSSATMCTSKPTPN1 | |
| SCHEMBL23200772 | 0.79 | PPARA (0.52) | PPARACTSSATMCTSKITGB3 | |
| SCHEMBL3811492 | 0.78 | ITGB3 (0.51) | CTSSATMCTSKITGB3ITGA2B | |
| SCHEMBL3814568 | 0.78 | ITGB3 (0.51) | CTSSATMCTSKITGB3ITGA2B | |
| SCHEMBL192406 | 0.77 | CTSS (0.54) | PPARACTSSATMCTSKPTPN1 | |
| SCHEMBL192405 | 0.77 | CTSS (0.54) | PPARACTSSATMCTSKPTPN1 | |
| SCHEMBL2574965 | 0.77 | CTSS (0.54) | PPARACTSSATMCTSKPTPN1 | |
| SCHEMBL2574963 | 0.77 | CTSS (0.54) | PPARACTSSATMCTSKPTPN1 | |
| SCHEMBL20439333 | 0.77 | CTSS (0.54) | PPARACTSSATMCTSKPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |