Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR5A | P47898 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CEL | P19835 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3692132 | 0.78 | TDO2 (0.38) | TP53 | |
| SCHEMBL247757 | 0.78 | TDO2 (0.38) | TP53 | |
| SCHEMBL4482096 | 0.78 | TDO2 (0.38) | TP53 | |
| SCHEMBL3793155 | 0.76 | TSHR (0.43) | HTR2CHTR1AHTR1DHTR7HTR5A | |
| SCHEMBL9017624 | 0.75 | LRRK2 (0.35) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3791245 | 0.74 | TSHR (0.41) | HTR2CHTR1AHTR1DHTR7HTR5A | |
| SCHEMBL3789871 | 0.72 | TSHR (0.43) | HTR2CHTR1AHTR1DHTR7HTR5A | |
| Nitrogen SCHEMBL11050859 | 0.72 | ALDH1A1 (0.40) | HTR2CHTR1AHTR1DHTR7HTR5A | |
| SCHEMBL27500344 | 0.72 | KDM4E (0.41) | TSHRCYP3A4TP53 | |
| SCHEMBL4478730 | 0.70 | PTGS1 (0.33) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |