Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648107 | 0.93 | ALDH1A1 (0.56) | ALDH1A1TDP1SMN1; SMN2LMNATP53 | |
| SCHEMBL6596927 | 0.91 | ALDH1A1 (0.49) | ALDH1A1TDP1SMN1; SMN2LMNATP53 | |
| SCHEMBL2648681 | 0.86 | GCK (0.53) | ALDH1A1TDP1SMN1; SMN2GCKPDE5A | |
| SCHEMBL2647253 | 0.85 | ALDH1A1 (0.54) | ALDH1A1TDP1SMN1; SMN2LMNATP53 | |
| SCHEMBL2647614 | 0.84 | GCK (0.49) | GCKPDE5AMME | |
| SCHEMBL2648137 | 0.83 | LTC4S (0.52) | ALDH1A1TDP1SMN1; SMN2LMNATP53 | |
| SCHEMBL2646210 | 0.83 | MAPT (0.59) | ALDH1A1TDP1SMN1; SMN2LMNAGCK | |
| SCHEMBL2647225 | 0.83 | GCK (0.68) | ALDH1A1TDP1SMN1; SMN2LMNAGCK | |
| SCHEMBL2646191 | 0.80 | ALDH1A1 (0.57) | ALDH1A1TDP1SMN1; SMN2LMNATP53 | |
| SCHEMBL2648531 | 0.80 | SMN1; SMN2 (0.55) | TDP1SMN1; SMN2LMNAGCKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282611-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001085706-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | disclosed |