Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 7/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656631 | 0.88 | NPC1 (0.67) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2654883 | 0.88 | NPC1 (0.67) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2654629 | 0.87 | GCG (0.55) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2654896 | 0.86 | S1PR1 (0.60) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2657107 | 0.86 | S1PR1 (0.66) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL15943176 | 0.86 | NPC1 (0.54) | S1PR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2655267 | 0.85 | RXRA (0.55) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2653847 | 0.85 | NPC1 (0.57) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2655880 | 0.84 | NPC1 (0.56) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2655022 | 0.84 | S1PR1 (0.58) | S1PR1S1PR3S1PR5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | claimed |
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |