Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659524 | 0.89 | GCK (0.45) | GCKPTGS2KMT2AHAO1GPR119 | |
| SCHEMBL2667440 | 0.84 | GCK (0.66) | GCK | |
| SCHEMBL2667759 | 0.83 | GCK (0.47) | GCKPTGS2F2F10 | |
| SCHEMBL1107736 | 0.82 | GCK (0.60) | GCKPTGS2KMT2A | |
| SCHEMBL2667675 | 0.81 | GCK (0.52) | GCK | |
| SCHEMBL9987882 | 0.80 | GCK (0.47) | GCKPTGS2 | |
| SCHEMBL851897 | 0.80 | SCN9A (0.50) | KMT2AF2F10 | |
| SCHEMBL2658908 | 0.79 | GCK (0.76) | GCK | |
| SCHEMBL2667679 | 0.79 | GCK (0.78) | GCKKMT2A | |
| SCHEMBL2656280 | 0.78 | KMT2A (0.52) | KMT2AF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |