Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941551 | 0.86 | PTGS2 (0.54) | GCKPTGS2ALDH1A1PTGS1 | |
| SCHEMBL2656722 | 0.80 | GCK (0.47) | GCKPTGS2 | |
| SCHEMBL8941703 | 0.79 | MEN1 (0.46) | PTGS2PTGS1 | |
| SCHEMBL2659524 | 0.77 | GCK (0.45) | GCKPTGS2 | |
| SCHEMBL9987457 | 0.76 | F2 (0.41) | ALDH1A1 | |
| SCHEMBL9987196 | 0.76 | GCK (0.62) | GCKPTGS2 | |
| SCHEMBL9034923 | 0.75 | PTGS2 (0.55) | GCKPTGS2PTGS1 | |
| SCHEMBL2523502 | 0.75 | KMT2A (0.42) | ALDH1A1 | |
| SCHEMBL8941557 | 0.74 | MAPT (0.56) | PTGS2ALDH1A1PTGS1 | |
| SCHEMBL9987674 | 0.74 | GCK (0.39) | GCKPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |