Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656821 | 0.84 | GABRA1 (0.44) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657323 | 0.84 | GABRA1 (0.49) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7001889 | 0.80 | GABRA1 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658899 | 0.79 | GABRG2 (0.44) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7003681 | 0.79 | GABRA1 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7002729 | 0.77 | GABRA1 (0.50) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2656469 | 0.71 | GABRA1 (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL340728 | 0.71 | GABRA1 (0.69) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6999735 | 0.69 | GABRA1 (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658367 | 0.69 | GABRA1 (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LTD. (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012505-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR TREATING ANXIETY AND ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |