Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17817590 | 0.98 | ADORA2A (0.64) | ADORA2ACYP2C9LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL7142997 | 0.98 | ADORA2A (0.64) | ADORA2ACYP2C9LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1854243 | 0.95 | ADORA2A (0.71) | ADORA2ACYP2C9LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL15480444 | 0.92 | ALDH1A1 (0.68) | LMNAALDH1A1USP2MAPK1NPC1 | |
| SCHEMBL15480447 | 0.90 | ALDH1A1 (0.67) | LMNAALDH1A1USP2MAPK1NPC1 | |
| SCHEMBL15480450 | 0.90 | ALDH1A1 (0.67) | LMNAALDH1A1USP2MAPK1NPC1 | |
| SCHEMBL15480445 | 0.90 | ALDH1A1 (0.67) | LMNAALDH1A1USP2MAPK1NPC1 | |
| SCHEMBL15480448 | 0.90 | ALDH1A1 (0.67) | LMNAALDH1A1USP2MAPK1NPC1 | |
| SCHEMBL4112093 | 0.89 | ADORA2A (0.70) | ADORA2ACYP2C9LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1860388 | 0.88 | L3MBTL1 (0.56) | ADORA2ACYP2C9LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091947-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| EP-2091947-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | disclosed |