Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619345 | 0.80 | HDAC6 (0.46) | ROCK2KDM4ERECQLPARGSMN1; SMN2 | |
| SCHEMBL8020584 | 0.79 | ROCK2 (0.47) | ROCK2KDM4EUSP30PARP1PARG | |
| SCHEMBL2118710 | 0.79 | HDAC6 (0.46) | KDM4ERECQLSMN1; SMN2HPGD | |
| SCHEMBL2723566 | 0.79 | KDM4E (0.49) | KDM4ERECQLPARP1GLAGAA | |
| SCHEMBL4550187 | 0.78 | HDAC6 (0.43) | ROCK2KDM4ERECQLPARP1PARG | |
| SCHEMBL29964971 | 0.77 | ROCK2 (0.49) | ROCK2KDM4EPARP1PARGTMIGD3 | |
| SCHEMBL29965128 | 0.77 | ROCK2 (0.46) | ROCK2KDM4ERECQLPARP1PARG | |
| SCHEMBL28004053 | 0.73 | PARP1 (0.62) | ROCK2PARP1PARGHPGD | |
| SCHEMBL16404341 | 0.73 | PARP1 (0.62) | ROCK2PARP1PARGHPGD | |
| SCHEMBL29965041 | 0.72 | TUBB4A (0.50) | ROCK2KDM4EPARP1PARGGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001875-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007104034-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-09-13 | — | — | WO | claimed |