Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656402 | 0.90 | MEN1 (0.64) | MEN1KMT2AMRGPRX4MAOBNR4A2 | |
| SCHEMBL2656457 | 0.87 | LMNA (0.56) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL4924745 | 0.83 | LMNA (0.58) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL391547 | 0.83 | MEN1 (0.71) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL2657646 | 0.83 | LMNA (0.49) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL2657040 | 0.81 | CA1 (0.53) | LMNAHPGDMRGPRX4 | |
| SCHEMBL183994 | 0.80 | LMNA (0.70) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL2657812 | 0.80 | GCK (0.54) | MEN1KMT2AGCK | |
| SCHEMBL3599122 | 0.80 | LMNA (0.53) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL29788280 | 0.79 | LMNA (0.65) | LMNAHPGDMEN1KMT2AMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078000-A1 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | AstraZeneca AB (SE) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008050117-A1 | BENZOYL AMINO HETEROCYCLYL COMPOUNDS AS GLUCOKINASE (GLK) ACTIVATORS | ASTRAZENECA AB (SE) | 2008-05-02 | — | — | WO | disclosed |