Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656365 | 0.89 | GCGR (0.40) | GCGRPPARDPPARGLMNATP53 | |
| SCHEMBL2656273 | 0.86 | GCGR (0.54) | GCGRPPARDEPHX2PPARGPPARA | |
| SCHEMBL5119133 | 0.83 | GCGR (0.44) | GCGRPPARDLMNANR1H2NR1H3 | |
| SCHEMBL2655238 | 0.83 | PPARD (0.39) | GCGRPPARDPPARGMAPTPPARA | |
| SCHEMBL2662634 | 0.80 | CA1 (0.44) | GCGREPHX2LMNA | |
| SCHEMBL2655395 | 0.80 | GCGR (0.41) | GCGRPPARDPPARGLMNATP53 | |
| SCHEMBL2657513 | 0.77 | LMNA (0.42) | GCGRPPARDLMNAMAPTPPARA | |
| SCHEMBL2655653 | 0.77 | LMNA (0.44) | GCGRPPARDLMNATP53MAPT | |
| SCHEMBL2655056 | 0.76 | GCGR (0.47) | GCGRPPARDMAPTPPARA | |
| SCHEMBL2656103 | 0.76 | GCGR (0.43) | GCGRPPARDEPHX2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951659-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007114855-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |