Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 16/20 | 0.67 |
| ▸ | MT-CO1 | P00395 | 2/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137597 | 0.94 | CCKAR (0.66) | CCKARMT-CO1CNR2 | |
| SCHEMBL12477368 | 0.90 | CCKAR (0.68) | CCKAR | |
| SCHEMBL3980545 | 0.90 | CCKAR (0.65) | CCKAR | |
| SCHEMBL2357628 | 0.88 | CCKAR (0.68) | CCKARMT-CO1CNR2 | |
| SCHEMBL3881950 | 0.88 | CCKAR (0.52) | CCKARMT-CO1CNR2 | |
| SCHEMBL3612093 | 0.83 | CCKAR (0.63) | CCKAR | |
| SCHEMBL502739 | 0.81 | CCKAR (1.00) | CCKAR | |
| SCHEMBL2152386 | 0.75 | CCKAR (0.92) | CCKAR | |
| SCHEMBL502712 | 0.75 | CCKAR (1.00) | CCKAR | |
| SCHEMBL502146 | 0.75 | CCKAR (1.00) | CCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940842-B1 | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-2079688-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008042223-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2008-04-10 | — | — | WO | disclosed |