SCHEMBL2657671

SCHEMBL2657671

Clc1ccc(SC2CC2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 2/20 0.47
DDB1 Q16531 1/20 0.47
MAOA P21397 5/20 0.44
MAOB P27338 5/20 0.44
MAPT P10636 3/20 0.41
HPGD P15428 3/20 0.41
ALDH1A1 P00352 2/20 0.41
POLB P06746 1/20 0.41
LMNA P02545 1/20 0.40
CYP2A6 P11509 1/20 0.40
NPC1 O15118 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
ALOX15 P16050 1/20 0.38
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
MITF O75030 1/20 0.36
TSHR P16473 1/20 0.36
CTSK P43235 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29695938 0.89 MAOA (0.58) CRBNDDB1MAOAMAOBMAPT
SCHEMBL4671081 0.85 CRBN (0.41) CRBNDDB1MAOAMAOBMAPT
SCHEMBL2795867 0.85 CYP1A2 (0.49) CRBNDDB1MAOAMAOBMAPT
Hydrochloric Acid SCHEMBL7476351 0.83 CYP1A2 (0.47) CRBNDDB1MAOAMAOBMAPT
SCHEMBL28024949 0.83 MAPT (0.47) CRBNDDB1MAPTHPGDALDH1A1
SCHEMBL18758727 0.82 POLB (0.50) CRBNDDB1POLB
SCHEMBL5223258 0.79 DDB1 (0.43) CRBNDDB1MAPTHPGDALDH1A1
SCHEMBL15152744 0.78 SMN1; SMN2 (0.47) MAPTHPGDALDH1A1LMNAALOX15
SCHEMBL15347584 0.78 SMN1; SMN2 (0.47) MAPTHPGDALDH1A1LMNAALOX15
SCHEMBL18748253 0.78 HRH3 (0.51) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1948645-A1 TRICYCLO SUBSTITUTED AMIDES Prosidion Limited (GB) 2008-07-30 EP disclosed
WO-2007051846-A1 TRICYCLO SUBSTITUTED AMIDES PROSIDION LTD (GB) 2007-05-10 WO disclosed
US-4233292-A ANTIOBESITY AGENTS SANDOZ, INC. (US) 1980-11-11 US disclosed