SCHEMBL2657751

SCHEMBL2657751

c1ccc(Nc2ccc3cccc-3o2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 4/20 0.47
FLT1 P17948 2/20 0.47
FLT4 P35916 2/20 0.47
NQO2 P16083 2/20 0.41
HSD17B10 Q99714 2/20 0.41
HPGD P15428 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
GSK3B P49841 1/20 0.41
GFER P55789 1/20 0.41
ALDH1A1 P00352 3/20 0.40
MAPT P10636 2/20 0.40
MEN1 O00255 1/20 0.40
AR P10275 1/20 0.40
KMT2A Q03164 1/20 0.40
MAPK1 P28482 2/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
ALOX12 P18054 1/20 0.39
PTGS1 P23219 1/20 0.39
SLC6A2 P23975 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29068394 0.79 HSD17B10 (0.58) KDRFLT1FLT4HSD17B10HPGD
SCHEMBL12230561 0.78 ALDH1A1 (0.56) KDRFLT1FLT4NQO2HSD17B10
SCHEMBL12230563 0.75 ALDH1A1 (0.52) KDRFLT1FLT4NQO2HSD17B10
SCHEMBL12230558 0.74 ALDH1A1 (0.50) KDRFLT1FLT4NQO2HSD17B10
SCHEMBL12230564 0.74 ALDH1A1 (0.50) KDRFLT1FLT4NQO2HSD17B10
SCHEMBL26365771 0.71 HRH1 (0.50) NQO2HSD17B10HPGDSMN1; SMN2GFER
SCHEMBL17194799 0.67 ALK (0.54) HSD17B10HPGDSMN1; SMN2GFERALDH1A1
SCHEMBL4344550 0.67 ALDH1A1 (0.61) NQO2HSD17B10HPGDSMN1; SMN2GFER
SCHEMBL4340657 0.67 ALDH1A1 (0.61) NQO2HSD17B10HPGDSMN1; SMN2GFER
SCHEMBL10079561 0.67 ALDH1A1 (0.77) HSD17B10HPGDGFERALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107698601-B Heterocyclic compound and organic electroluminescent element comprising same 株式会社LG化学 2022-01-04 CN disclosed
US-10807946-B2 Antagonists of the glucagon receptor METABASIS THERAPEUTICS, INC. (US) 2020-10-20 US disclosed
US-20190218176-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-07-18 US disclosed
US-10239829-B2 Antagonists of the glucagon receptor METABASIS THERAPEUTICS, INC. (US) 2019-03-26 US disclosed
EP-2786985-B1 Antagonists of the glucagon receptor METABASIS THERAPEUTICS INC (US) 2018-11-28 EP disclosed
US-20170275246-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR METABASIS THERAPEUTICS, INC. 2017-09-28 US disclosed
US-9701626-B2 Antagonists of the glucagon receptor METABASIS THERAPEUTICS, INC. (US) 2017-07-11 US disclosed
US-20160009639-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR METABASIS THERAPEUTICS INC (US) 2016-01-14 US disclosed
US-9169201-B2 Antagonists of the glucagon receptor METABASIS THERAPEUTICS, INC. (US) 2015-10-27 US disclosed
EP-2786985-A2 Antagonists of the glucagon receptor Metabasis Therapeutics, Inc. (US) 2014-10-08 EP disclosed
EP-2129654-B1 ANTAGONISTS OF THE GLUCAGON RECEPTOR METABASIS THERAPEUTICS INC (US) 2014-05-28 EP disclosed
US-20140135400-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR METABASIS THERAPEUTICS, INC. (US) 2014-05-15 US disclosed
US-8710236-B2 Antagonists of the glucagon receptor METABASIS THERAPEUTICS, INC. (US) 2014-04-29 US disclosed
US-20120214769-A1 Novel Antagonists of the Glucagon Receptor METABASIS THERAPEUTICS, INC. (US) 2012-08-23 US disclosed
EP-2129654-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR Metabasis Therapeutics, Inc. (US) 2009-12-09 EP disclosed
WO-2008098244-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR METABASIS THERAPEUTICS, INC. (US) 2008-08-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160009639-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR GLP1R, GCGR, GPR119 KDR 2713/4885FLT1 926/4885FLT4 1670/4885
US-20190218176-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR GLP1R, GCGR, GPR119 KDR 2769/4885FLT1 951/4885FLT4 1703/4885
US-10239829-B2 Antagonists of the glucagon receptor GLP1R, GCGR, GPR119 KDR 2782/4885FLT1 926/4885FLT4 1671/4885
US-20140135400-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR GLP1R, GCGR, GPR119 KDR 2713/4885FLT1 926/4885FLT4 1670/4885
US-20120214769-A1 Novel Antagonists of the Glucagon Receptor GLP1R, GCGR, GPR119 KDR 2713/4885FLT1 926/4885FLT4 1670/4885
US-20170275246-A1 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR GLP1R, GCGR, GPR119 KDR 2713/4885FLT1 926/4885FLT4 1670/4885
US-10807946-B2 Antagonists of the glucagon receptor GLP1R, GCGR, GPR119 KDR 2744/4885FLT1 928/4885FLT4 1675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.