Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | WNT3A | P56704 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350012 | 0.86 | PLK1 (0.44) | ALDH1A1MAPK1SMN1; SMN2KDM4ETPMT | |
| SCHEMBL6345461 | 0.86 | KMT2A (0.42) | ALDH1A1MAPK1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL17714985 | 0.81 | RAB9A (0.49) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL1811267 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPK1SRD5A2SMN1; SMN2KDM4E | |
| SCHEMBL25391509 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1SRD5A2SMN1; SMN2KDM4E | |
| SCHEMBL13671456 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1SRD5A2SMN1; SMN2KDM4E | |
| SCHEMBL3705853 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1SRD5A2SMN1; SMN2KDM4E | |
| SCHEMBL23809420 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPK1SRD5A2SMN1; SMN2MEN1 | |
| SCHEMBL4938172 | 0.78 | PLK1 (0.55) | ALDH1A1MAPK1SMN1; SMN2KDM4ETPMT | |
| SCHEMBL4422910 | 0.76 | ALDH1A1 (0.46) | ALDH1A1MAPK1SRD5A2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ALDH1A1 2556/4885MAPK1 1843/4885SRD5A2 4675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.