Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101663 | 0.77 | — | — | |
| SCHEMBL12021220 | 0.75 | ALDH1A1 (0.40) | ALDH1A1DPP4APPCYP2E1CYP3A4 | |
| SCHEMBL2656076 | 0.74 | ALDH1A1 (0.41) | ALDH1A1DPP4 | |
| SCHEMBL2656079 | 0.73 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL12021053 | 0.72 | ALDH1A1 (0.40) | ALDH1A1DPP4 | |
| 2,5-Thiophenenedicarboxaldehyde SCHEMBL17477277 | 0.72 | ALDH1A1 (0.53) | ALDH1A1DPP4APPCYP2E1CYP3A4 | |
| SCHEMBL21101858 | 0.70 | FDPS (0.43) | ALDH1A1 | |
| SCHEMBL4729982 | 0.66 | DAO (0.41) | ALDH1A1 | |
| SCHEMBL22342723 | 0.65 | HSD17B3 (0.44) | ALDH1A1 | |
| SCHEMBL158329 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185570-B1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS INC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2185570-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | Metabasis Therapeutics, Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009023718-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |