Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG2 | P16885 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660077 | 0.92 | ALDH1A1 (0.36) | PLCG2ALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL2978405 | 0.92 | ACKR3 (0.36) | PLCG2ALDH1A1ACKR3 | |
| SCHEMBL2976696 | 0.87 | PLCG2 (0.33) | PLCG2ALDH1A1SMN1; SMN2ACKR3RAB9A | |
| SCHEMBL2661597 | 0.87 | HDAC8 (0.32) | PLCG2RAB9A | |
| SCHEMBL2978211 | 0.85 | HCRTR1 (0.37) | ALDH1A1SMN1; SMN2LMNAHPGDRAB9A | |
| SCHEMBL2659425 | 0.84 | SMN1; SMN2 (0.35) | PLCG2ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2660548 | 0.83 | PLCG2 (0.39) | PLCG2ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2660525 | 0.82 | HCRTR1 (0.37) | ALDH1A1SMN1; SMN2LMNAHPGDPKM | |
| SCHEMBL2659436 | 0.82 | PLCG2 (0.36) | PLCG2ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2970926 | 0.82 | PLCG2 (0.38) | PLCG2ALDH1A1MAPTLMNAACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |