Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978211 | 0.93 | HCRTR1 (0.37) | ALDH1A1KDM4EHSD17B10HCRTR1SMN1; SMN2 | |
| SCHEMBL2659017 | 0.92 | PLCG2 (0.34) | ALDH1A1SMN1; SMN2PLCG2LMNARAB9A | |
| SCHEMBL2976696 | 0.91 | PLCG2 (0.33) | ALDH1A1KDM4EHSD17B10HCRTR1SMN1; SMN2 | |
| SCHEMBL2660525 | 0.90 | HCRTR1 (0.37) | ALDH1A1KDM4EHSD17B10HCRTR1SMN1; SMN2 | |
| SCHEMBL2659804 | 0.89 | CTSS (0.33) | ALDH1A1KDM4EHSD17B10HCRTR1TSHR | |
| SCHEMBL2978405 | 0.88 | ACKR3 (0.36) | ALDH1A1PLCG2 | |
| SCHEMBL2661597 | 0.87 | HDAC8 (0.32) | PLCG2RAB9A | |
| SCHEMBL2668833 | 0.87 | ALDH1A1 (0.37) | ALDH1A1KDM4EHSD17B10SMN1; SMN2PLCG2 | |
| SCHEMBL2668868 | 0.87 | HCRTR1 (0.34) | ALDH1A1KDM4EHSD17B10HCRTR1TSHR | |
| SCHEMBL2662040 | 0.86 | MAPT (0.36) | ALDH1A1KDM4EHSD17B10SMN1; SMN2PLCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410087-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-04-02 | — | — | US | disclosed |
| US-8410087-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-04-02 | — | — | US | disclosed |
| US-8410087-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-04-02 | — | — | US | disclosed |
| EP-2508524-A2 | Indole compound | Takeda Pharmaceutical Company Limited (JP) | 2012-10-10 | — | — | EP | disclosed |
| US-7777047-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-17 | — | — | US | disclosed |
| US-7777047-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-17 | — | — | US | disclosed |
| US-7777047-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-17 | — | — | US | disclosed |
| US-7767811-B2 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids | BRANDEIS UNIVERSITY (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100144702-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | US | disclosed |
| US-20100144702-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | US | disclosed |
| US-6743914-B2 | USING TERTIARY AMINE CATALYST | BRANDEIS UNIVERSITY | 2004-06-01 | — | — | US | disclosed |
| EP-1419125-A1 | KINETIC RESOLUTIONS OF CHIRAT 3- AND 3-SUBSTITUTED CARBOXYLIC ACIDS | Brandeis University (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-1305270-B1 | KINETIC RESOLUTIONS OF CHIRAL 2- AND 3-SUBSTITUTED CARBOXYLIC ACIDS | UNIV BRANDEIS (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20030166963-A1 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-09-04 | — | — | US | disclosed |
| US-6562967-B2 | Drug screening; purity | BRANDEIS UNIVERSITY | 2003-05-13 | — | — | US | disclosed |
| EP-1305270-A1 | KINETIC RESOLUTIONS OF CHIRAL 2- AND 3-SUBSTITUTED CARBOXYLIC ACIDS | Brandeis University (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2003011799-A1 | KINETIC RESOLUTIONS OF CHIRAT 3- AND 3-SUBSTITUTED CARBOXYLIC ACIDS | BRANDEIS UNIVERSITY (US) | 2003-02-13 | — | — | WO | disclosed |
| US-20020165393-A1 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-11-07 | — | — | US | disclosed |
| US-20020151744-A1 | Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-10-17 | — | — | US | disclosed |
| WO-2002010096-A1 | KINETIC RESOLUTIONS OF CHIRAL 2- AND 3-SUBSTITUTED CARBOXYLIC ACIDS | BRANDEIS UNIVERSITY (US) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144702-A1 | INDOLE COMPOUND | GCKR, GPR119, SLC5A1 | ALDH1A1 376/4885KDM4E 1017/4885HSD17B10 579/4885 |
| US-20020165393-A1 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids | ADH5, ADH1C, TST | ALDH1A1 231/4885KDM4E 1172/4885HSD17B10 394/4885 |
| US-20030166963-A1 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids | ADH5, ADH1C, TST | ALDH1A1 225/4885KDM4E 1159/4885HSD17B10 446/4885 |
| US-20020151744-A1 | Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids | ADH5, ADH1C, TST | ALDH1A1 218/4885KDM4E 1263/4885HSD17B10 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.