Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968748 | 1.00 | KCNH2 (0.41) | KCNH2EGLN2ALDH1A1LMNAMAPT | |
| SCHEMBL30323005 | 0.86 | ALDH1A1 (0.52) | KCNH2ALDH1A1LMNAMAPTMET | |
| SCHEMBL22712090 | 0.86 | ALDH1A1 (0.52) | KCNH2ALDH1A1LMNAMAPTMET | |
| SCHEMBL26131907 | 0.83 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTMAPK1HTT | |
| SCHEMBL26590306 | 0.83 | PDE10A (0.41) | KCNH2ALDH1A1LMNAMAPTMET | |
| SCHEMBL29969656 | 0.83 | PDE10A (0.41) | KCNH2ALDH1A1LMNAMAPTMET | |
| SCHEMBL29970093 | 0.79 | GPR119 (0.40) | KCNH2ALDH1A1GPR119RETMAPK1 | |
| SCHEMBL25447173 | 0.77 | GPR119 (0.54) | EGLN2MAPTGPR119RETNR1H2 | |
| SCHEMBL28675410 | 0.77 | GPR119 (0.46) | KCNH2ALDH1A1LMNAMAPTMET | |
| SCHEMBL29503589 | 0.77 | GPR119 (0.46) | KCNH2ALDH1A1LMNAMAPTMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |