Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660055 | 0.91 | MAPT (0.39) | MAPTTP53LMNATHRBPOLB | |
| SCHEMBL2660420 | 0.90 | MAPT (0.40) | MAPTTP53LMNATHRBPOLB | |
| SCHEMBL2661032 | 0.89 | MAPT (0.35) | MAPTTP53LMNATHRBSLC40A1 | |
| SCHEMBL2660775 | 0.87 | MAPT (0.43) | MAPTTP53LMNATHRBPOLB | |
| SCHEMBL2658758 | 0.86 | MAPT (0.33) | MAPTTP53LMNATHRBSLC40A1 | |
| SCHEMBL2660519 | 0.85 | HDAC3 (0.35) | MAPTTP53LMNATHRBNSD2 | |
| SCHEMBL2660945 | 0.84 | MAPT (0.33) | MAPTTP53LMNATHRBPOLB | |
| SCHEMBL2659947 | 0.84 | ALDH1A1 (0.40) | TP53 | |
| SCHEMBL2661627 | 0.82 | F10 (0.33) | MAPTTP53LMNATHRBPOLB | |
| SCHEMBL2661196 | 0.81 | LMNA (0.38) | MAPTTP53LMNATHRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |