Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 4/20 | 0.59 |
| ▸ | MAOA | P21397 | 3/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | AGXT | P21549 | 2/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | RXRG | P48443 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL10801030 | 0.95 | HCAR2 (0.56) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL6709375 | 0.87 | ALDH1A1 (0.73) | ALDH1A1HCAR2MAOBCYP3A4KDM4E | |
| SCHEMBL27577784 | 0.85 | HCAR2 (0.64) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL20267796 | 0.85 | CYP3A4 (0.58) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL134801 | 0.84 | ALDH1A1 (0.63) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL11740218 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL13667239 | 0.83 | MAOB (0.49) | ALDH1A1HCAR2MAOBMAOAHPGD | |
| SCHEMBL13467287 | 0.83 | HCAR2 (0.57) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL7975207 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HCAR2MAOBMAOAMMP1 | |
| SCHEMBL20083591 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HCAR2MAOBMAOAMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58008005-A | — | — | None | — | — | JP | disclosed |
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021188620-A1 | PEPTIDOMIMETIC N5-METHYL-N2-(NONANOYL-L-LEUCYL)-L-GLUTAMINATE DERIVATIVES, TRIAZASPIRO[4.14]NONADECANE DERIVATIVES AND SIMILAR COMPOUNDS AS INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION | COCRYSTAL PHARMA INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| EP-3341007-B1 | MALT1 INHIBITORS AND USES THEREOF | UNIV CORNELL (US) | 2020-12-23 | — | — | EP | disclosed |
| US-10711036-B2 | MALT1 inhibitors and uses thereof | CORNELL UNIVERSITY (US) | 2020-07-14 | — | — | US | disclosed |
| WO-2017040304-A1 | MALT1 INHIBITORS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2017-03-09 | — | — | WO | disclosed |
| US-7825149-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2010-11-02 | — | — | US | disclosed |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-7592362-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-7544706-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-09 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | PFIZER INC. (US) | 2007-07-19 | — | — | US | disclosed |
| US-20040097557-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | DUFFY JOSEPH L (US) | 2004-05-20 | — | — | US | disclosed |
| CN-1413190-A | EP4 receptor selective agonists in treatment of osteoporosis | PFIZER PROD INC (US) | 2003-04-23 | — | — | CN | disclosed |
| US-6278019-B1 | REACTING ALKYL GROUP SUBSTITUTED AROMATIC COMPOUND AND A CARBOXYLIC ACID AND/OR A CARBOXYLIC ANHYDRIDE IN PRESENCE OF OXYGEN CONTAINING GAS AND SOLID CATALYST SELECTED FROM COABLT, CERIUM AND MANGANESE SUPPORTED ON SOLID SUPPORT | TORAY INDUSTRIES, INC. (JP) | 2001-08-21 | — | — | US | disclosed |
| EP-0963974-A1 | PROCESS FOR ACYLOXYLATING SIDE CHAINS OF ALKYL-SUBSTITUTED AROMATIC COMPOUNDS AND CATALYSTS USED THEREFOR | TORAY INDUSTRIES, INC. (JP) | 1999-12-15 | — | — | EP | disclosed |
| US-4709081-A | ETHERIFICATION, HYDROLYSIS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1987-11-24 | — | — | US | disclosed |
| JP-S588005-A | REPELLENT FOR NOXIOUS INSECT | EARTH CHEM CORP LTD | 1983-01-18 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | ALDH1A1 617/4885HCAR2 3540/4885MAOB 186/4885 |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | ALDH1A1 617/4885HCAR2 3540/4885MAOB 186/4885 |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | ALDH1A1 617/4885HCAR2 3540/4885MAOB 186/4885 |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | ALDH1A1 617/4885HCAR2 3540/4885MAOB 186/4885 |
| US-10711036-B2 | MALT1 inhibitors and uses thereof | MALT1, BCL3, BCL6 | ALDH1A1 2550/4885HCAR2 2887/4885MAOB 1834/4885 |
| US-20040097557-A1 | Cyanothiophene derivatives, compositions containing such compounds and methods of use | GLP1R, GPR119, GCGR | ALDH1A1 2652/4885HCAR2 437/4885MAOB 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.