Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180230 | 0.81 | LMNA (0.43) | LMNAAKR1C3AKR1C2 | |
| SCHEMBL1622103 | 0.80 | MYC (0.42) | LMNAAKR1C3AKR1C1MEN1KMT2A | |
| SCHEMBL2706652 | 0.80 | CA12 (0.41) | MEN1KMT2AALDH1A1CA12CA1 | |
| SCHEMBL2642568 | 0.80 | CSNK2A1 (0.42) | MEN1KMT2AALDH1A1CA12CA1 | |
| SCHEMBL2642632 | 0.78 | PTGDR2 (0.42) | MEN1KMT2AALDH1A1PLA2G4APTGDR2 | |
| SCHEMBL2643375 | 0.78 | PTGDR2 (0.40) | LMNAALDH1A1PTGDR2CA12CA1 | |
| SCHEMBL2643062 | 0.77 | MCL1 (0.47) | AKR1C3AKR1C2MEN1KMT2ACA12 | |
| SCHEMBL2643559 | 0.77 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2643501 | 0.76 | KDM4E (0.48) | LMNAAKR1C3AKR1C2ALDH1A1CA12 | |
| SCHEMBL2642800 | 0.75 | ALDH1A1 (0.44) | MEN1KMT2ACNR1CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549638-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031179-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-15 | — | — | WO | disclosed |