Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659077 | 0.93 | NSD2 (0.33) | NSD2PLCG2HDAC3HDAC1PLA2G7 | |
| SCHEMBL2659227 | 0.89 | NSD2 (0.35) | NSD2PLCG2HDAC3HDAC1PLA2G7 | |
| SCHEMBL2659093 | 0.88 | NSD2 (0.36) | NSD2PLCG2HDAC3HDAC1PLA2G7 | |
| SCHEMBL2659972 | 0.87 | MCL1 (0.33) | NSD2PLCG2HDAC3HDAC1PLA2G7 | |
| SCHEMBL2660563 | 0.85 | HDAC3 (0.36) | NSD2PLCG2HDAC3HDAC1PLA2G7 | |
| SCHEMBL2659423 | 0.84 | HRH4 (0.32) | NSD2PLCG2HDAC3HDAC1MAPT | |
| SCHEMBL2660564 | 0.84 | KDM4E (0.37) | MAPTMAPK1 | |
| SCHEMBL2661515 | 0.81 | MAPK8 (0.33) | MAPT | |
| SCHEMBL2660519 | 0.80 | HDAC3 (0.35) | NSD2PLCG2HDAC3HDAC1PLA2G7 | |
| SCHEMBL2660248 | 0.79 | NSD2 (0.33) | NSD2PLCG2HDAC3HDAC1PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |