Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660564 | 0.92 | KDM4E (0.37) | LMNAMAPT | |
| SCHEMBL2661515 | 0.89 | MAPK8 (0.33) | LMNATP53MAPT | |
| SCHEMBL2659227 | 0.86 | NSD2 (0.35) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2659015 | 0.85 | HDAC3 (0.32) | HRH4PKMNSD2HDAC3HDAC1 | |
| SCHEMBL2659696 | 0.84 | NSD2 (0.37) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2659433 | 0.83 | NSD2 (0.33) | HRH4NSD2HDAC3HDAC1PLCG2 | |
| SCHEMBL2659093 | 0.82 | NSD2 (0.36) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2659972 | 0.81 | MCL1 (0.33) | NSD2HDAC3HDAC1PLCG2LMNA | |
| SCHEMBL2659077 | 0.81 | NSD2 (0.33) | NSD2HDAC3HDAC1PLCG2LMNA | |
| SCHEMBL2659425 | 0.80 | SMN1; SMN2 (0.35) | PKMPLCG2LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |