Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659696 | 0.87 | NSD2 (0.37) | MCL1NSD2HDAC3HDAC1PLCG2 | |
| SCHEMBL2659227 | 0.86 | NSD2 (0.35) | MCL1NSD2HDAC3HDAC1PLCG2 | |
| SCHEMBL2659093 | 0.85 | NSD2 (0.36) | MCL1NSD2HDAC3HDAC1PLCG2 | |
| SCHEMBL2659077 | 0.84 | NSD2 (0.33) | MCL1NSD2HDAC3HDAC1PLCG2 | |
| SCHEMBL2660519 | 0.83 | HDAC3 (0.35) | NSD2HDAC3HDAC1PLCG2TUBB4A | |
| SCHEMBL2659423 | 0.81 | HRH4 (0.32) | NSD2HDAC3HDAC1PLCG2MAPT | |
| SCHEMBL2660564 | 0.81 | KDM4E (0.37) | MAPTLMNA | |
| SCHEMBL2660563 | 0.81 | HDAC3 (0.36) | NSD2HDAC3HDAC1PLCG2PLA2G7 | |
| SCHEMBL2661515 | 0.79 | MAPK8 (0.33) | MAPTLMNATP53 | |
| SCHEMBL2659974 | 0.78 | PLCG2 (0.36) | PLCG2MAPTLMNATP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |