Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660015 | 0.83 | GABRA1 (0.34) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL5739550 | 0.80 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL183662 | 0.78 | MAPK9 (0.42) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL2659070 | 0.74 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5776721 | 0.74 | KDM4E (0.32) | — | |
| SCHEMBL2658781 | 0.73 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL2658952 | 0.73 | GABRA1 (0.32) | GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL2658693 | 0.73 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659092 | 0.72 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2660285 | 0.72 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511748-B1 | 8-FLUORIMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-08-09 | — | — | EP | disclosed |
| EP-1511747-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-04-12 | — | — | EP | disclosed |
| EP-1511747-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003099816-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2003-12-04 | — | — | WO | disclosed |