Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25245121 | 0.76 | HDAC8 (0.45) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL2659705 | 0.74 | GABRA1 (0.48) | — | |
| SCHEMBL23104791 | 0.73 | IKBKB (0.33) | — | |
| SCHEMBL5777594 | 0.72 | PRMT5 (0.39) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL31329960 | 0.69 | GRIN2D (0.33) | L3MBTL1 | |
| SCHEMBL1368540 | 0.66 | PARP1 (0.41) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL14321728 | 0.65 | LCK (0.31) | — | |
| SCHEMBL23104611 | 0.64 | USP7 (0.40) | KDM4EMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL23089243 | 0.64 | FLT3 (0.40) | KDM4EALDH1A1 | |
| SCHEMBL22200842 | 0.64 | HDAC8 (0.45) | KDM4ENPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511747-B1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-04-12 | — | — | EP | disclosed |