Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 11/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929726 | 0.88 | DRD2 (0.47) | DRD2HRH4DRD4HRH1HRH2 | |
| SCHEMBL21887284 | 0.86 | DRD2 (0.43) | DRD2HRH4DRD4HRH1HRH2 | |
| SCHEMBL11925296 | 0.84 | DRD2 (0.42) | DRD2HRH4DRD4HRH1HRH2 | |
| SCHEMBL24199399 | 0.78 | DRD2 (0.41) | DRD2HRH4DRD4DRD1ADRA2A | |
| SCHEMBL23125443 | 0.77 | DRD2 (0.41) | DRD2HRH4DRD4DRD1LMNA | |
| SCHEMBL23125441 | 0.77 | DRD1 (0.40) | DRD2HRH4DRD4DRD1LMNA | |
| SCHEMBL15047809 | 0.77 | DRD2 (0.40) | DRD2HRH4DRD4DRD1LMNA | |
| SCHEMBL24199398 | 0.76 | DRD2 (0.40) | DRD2HRH4DRD4DRD1LMNA | |
| SCHEMBL20751555 | 0.76 | DRD2 (0.40) | DRD2HRH4DRD4DRD1LMNA | |
| SCHEMBL20751562 | 0.75 | DRD2 (0.38) | DRD2HRH4DRD4DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118807068-A | Novel targets for the treatment or diagnosis of mood disorders or stress disorders and uses thereof | 浙江大学 | 2024-10-22 | — | — | CN | disclosed |
| CN-117500561-A | Novel targets for the treatment or diagnosis of mood disorders or stress disorders and uses thereof | 浙江大学 | 2024-02-02 | — | — | CN | disclosed |
| WO-2023202682-A1 | NOVEL TARGET FOR TREATING OR DIAGNOSING EMOTIONAL DISORDERS OR STRESS DISORDERS, AND APPLICATION THEREOF | 浙江大学 | 2023-10-26 | — | — | WO | disclosed |
| CN-114668765-B | Application of clozapine N-oxide in preparation of medicine for preventing and treating nitrogen anesthesia | 南通大学 | 2023-06-02 | — | — | CN | disclosed |
| CN-114668765-A | Application of clozapine N-oxide in preparation of medicine for preventing and treating nitrogen anesthesia | 南通大学 | 2022-06-28 | — | — | CN | disclosed |