Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652392 | 0.86 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP2A6KMT2AKDM4E | |
| SCHEMBL28300994 | 0.84 | CYP11B1 (0.59) | CYP11B1CYP11B2CYP2A6KMT2AKDM4E | |
| SCHEMBL2659447 | 0.79 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP2A6KMT2ACYP17A1 | |
| SCHEMBL19257504 | 0.79 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP2A6KMT2AKDM4E | |
| SCHEMBL21588612 | 0.79 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP2A6KMT2AKDM4E | |
| SCHEMBL21044098 | 0.79 | AXL (0.56) | CYP11B1CYP11B2CYP2A6KDM4EMEN1 | |
| SCHEMBL2402017 | 0.77 | CYP2A6 (0.54) | CYP2A6MAPK1ALDH1A1CYP19A1NPSR1 | |
| SCHEMBL2649040 | 0.76 | CYP11B2 (0.54) | CYP11B1CYP11B2CYP2A6KMT2AMAPK1 | |
| SCHEMBL6222583 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP2A6KMT2AKDM4E | |
| SCHEMBL551165 | 0.76 | NPC1 (0.65) | CYP11B1CYP2A6KDM4EHTTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381606-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002074773-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |