Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SI | P14410 | 3/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26599304 | 0.85 | CYP3A4 (0.52) | MGAMGAASIMGAM2CYP3A4 | |
| SCHEMBL22717376 | 0.80 | NPC1 (0.46) | MGAMGAASIMGAM2RAB9A | |
| SCHEMBL22717835 | 0.80 | PTGS1 (0.50) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL22717405 | 0.80 | ALDH1A1 (0.54) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL22717882 | 0.80 | ALDH1A1 (0.54) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL10821887 | 0.79 | GAA (0.60) | MGAMGAASIMGAM2CYP3A4 | |
| SCHEMBL24500409 | 0.76 | MGAM (0.40) | MGAMGAASIMGAM2RAB9A | |
| SCHEMBL22717603 | 0.75 | MGAM (0.40) | MGAMGAASIMGAM2CYP3A4 | |
| SCHEMBL22717606 | 0.73 | MGAM (0.45) | MGAMGAASIMGAM2RAB9A | |
| SCHEMBL22717753 | 0.73 | ALDH1A1 (0.41) | MGAMGAASIMGAM2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974043-A | Polq inhibitor compounds and uses thereof | 南京再明医药有限公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023202623-A1 | POLQ INHIBITOR COMPOUND AND USE THEREOF | 南京再明医药有限公司 | 2023-10-26 | — | — | WO | disclosed |