Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661009 | 0.90 | MAPT (0.34) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2661318 | 0.90 | HSD17B10 (0.32) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL12971365 | 0.87 | TSHR (0.32) | SMN1; SMN2HSD17B10LMNATSHRMEN1 | |
| SCHEMBL2660344 | 0.85 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2668816 | 0.85 | NR1H3 (0.33) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2971448 | 0.84 | RAB9A (0.34) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2968130 | 0.84 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2964370 | 0.84 | NR1H3 (0.36) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2968976 | 0.84 | NR1H3 (0.32) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA | |
| SCHEMBL2661093 | 0.84 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HSD17B10MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |