Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 12/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 7/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 7/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 7/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.38 |
| ▸ | CSNK1G3 | Q9Y6M4 | 5/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380990 | 0.88 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL5385996 | 0.87 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL5396362 | 0.85 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL5391496 | 0.85 | GABRA1 (0.50) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL2660756 | 0.84 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL2658731 | 0.84 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL2660454 | 0.83 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL5738295 | 0.81 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3MAPK9 | |
| SCHEMBL5769015 | 0.81 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659604 | 0.80 | GABRA1 (0.48) | GABRA1GABRG2GABRB3GABRA3MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226926-B2 | 8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. (GB) | 2007-06-05 | — | — | US | claimed |
| EP-1511748-B1 | 8-FLUORIMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-08-09 | — | — | EP | claimed |
| EP-1511748-A1 | 8-FLUORIMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-03-09 | — | — | EP | claimed |
| WO-2003099817-A1 | 8-FLUORIMIDAZO`1,2-A!PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2003-12-04 | — | — | WO | claimed |
| EP-1511748-B1 | 8-FLUORIMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-08-09 | — | — | EP | disclosed |