Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 18/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 18/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 18/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 15/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660283 | 0.88 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659945 | 0.88 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5738200 | 0.86 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5396493 | 0.85 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5384321 | 0.84 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659968 | 0.84 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5384206 | 0.84 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5385996 | 0.83 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659412 | 0.83 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5768854 | 0.83 | GABRA1 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226926-B2 | 8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. (GB) | 2007-06-05 | — | — | US | claimed |
| EP-1511748-B1 | 8-FLUORIMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-08-09 | — | — | EP | claimed |
| EP-1511748-B1 | 8-FLUORIMIDAZO(1,2-A)PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-08-09 | — | — | EP | disclosed |