Sugi Predict

Sugi Predict / Compounds / SCHEMBL26601006

SCHEMBL26601006

SCHEMBL26601006

C=C[C@@]1(C(O)[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)O[C@@H](n2cc(F)c(=O)[nH]c2=O)[C@H](OC(C)=O)[C@@H]1OCc1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ TYMS P04818 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ PMP22 Q01453 1/20 0.31
▸ HBB P68871 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ TK2 O00142 1/20 0.31
▸ HSP90AA1 P07900 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30670586 0.82 TDP1 (0.31) TDP1TSHRLMNAMAPTPMP22
SCHEMBL25401212 0.82 TDP1 (0.31) TDP1TSHRLMNAMAPTPMP22
SCHEMBL25400259 0.81 TSHR (0.34) TYMSTSHRLMNAMAPTPMP22
SCHEMBL25400267 0.81 TSHR (0.34) TYMSTSHRLMNAMAPTPMP22
SCHEMBL25403033 0.76 TSHR (0.35) TYMSTSHRLMNAMAPTPMP22
SCHEMBL25403028 0.76 TSHR (0.35) TYMSTSHRLMNAMAPTPMP22
SCHEMBL26123133 0.76 LMNA (0.36) TYMSTSHRLMNAMAPTPMP22
SCHEMBL26123128 0.76 LMNA (0.36) TYMSTSHRLMNAMAPTPMP22
SCHEMBL25397971 0.75 TSHR (0.35) TYMSTSHRLMNAMAPTPMP22
SCHEMBL25397967 0.75 TSHR (0.35) TYMSTSHRLMNAMAPTPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023178133-A9 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. (US) 2023-10-26 — — WO disclosed