Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 6/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | AR | P10275 | 2/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KRAS | P01116 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19183188 | 0.89 | MAOB (0.72) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL19183190 | 0.89 | MAOB (0.72) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL26605004 | 0.85 | AURKA (0.61) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL30918537 | 0.85 | MAOB (0.69) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL1938117 | 0.85 | MAPT (0.69) | MAOBMAOAARNR1H4NFE2L2 | |
| SCHEMBL1938113 | 0.85 | MAPT (0.69) | MAOBMAOAARNR1H4NFE2L2 | |
| SCHEMBL19183398 | 0.84 | NFE2L2 (0.67) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL19183397 | 0.84 | NFE2L2 (0.67) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL26604971 | 0.84 | MAOB (0.70) | AURKAMAOBMAOAARNR1H4 | |
| SCHEMBL19183470 | 0.81 | AURKA (0.66) | AURKAMAOBMAOAARNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511018-A1 | 4-CHROMONE DERIVATIVES AS N-POLYMERASE INHIBITORS FOR USE IN THE TREATMENT PLATINUM RESISTANT METASTATIC NEOPLASM | Fondazione Istituto Italiano di Tecnologia (IT) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023203535-A1 | 4-CHROMONE DERIVATIVES AS N-POLYMERASE INHIBITORS FOR USE IN THE TREATMENT PLATINUM RESISTANT METASTATIC NEOPLASM | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023203535-A1 | 4-CHROMONE DERIVATIVES AS N-POLYMERASE INHIBITORS FOR USE IN THE TREATMENT PLATINUM RESISTANT METASTATIC NEOPLASM | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2023-10-26 | — | — | WO | disclosed |