Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660014 | 0.92 | KDM4E (0.40) | KDM4ETSHRMAPTPOLBALDH1A1 | |
| SCHEMBL1653070 | 0.86 | MEN1 (0.45) | TSHRMAPTPOLBALDH1A1LMNA | |
| SCHEMBL2659841 | 0.84 | KDM4E (0.40) | KDM4ETSHRMAPTPOLBALDH1A1 | |
| SCHEMBL1653442 | 0.79 | MEN1 (0.46) | TSHRMAPTPOLBALDH1A1LMNA | |
| SCHEMBL1653233 | 0.75 | MEN1 (0.45) | KDM4ETSHRMAPTPOLBALDH1A1 | |
| SCHEMBL1653818 | 0.74 | KMT2A (0.41) | KDM4ETSHRMAPTPOLBALDH1A1 | |
| SCHEMBL1653065 | 0.71 | PKM (0.37) | KDM4ETSHRMAPTPOLBALDH1A1 | |
| SCHEMBL13203225 | 0.71 | PKM (0.39) | KDM4ETSHRMAPTPOLBALDH1A1 | |
| SCHEMBL1654094 | 0.70 | ALDH1A1 (0.50) | TSHRMAPTPOLBALDH1A1LMNA | |
| SCHEMBL15888939 | 0.68 | KDM4E (0.38) | KDM4ETSHRMAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |