Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26699002 | 0.86 | KDM4E (0.34) | KDM4EPOLBSMN1; SMN2TDP1MAPT | |
| SCHEMBL30593860 | 0.85 | AKR1C3 (0.36) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26611226 | 0.85 | KDM4E (0.40) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26698621 | 0.81 | CYP2C19 (0.48) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26612297 | 0.81 | KDM4E (0.62) | KDM4EPOLBALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL26699477 | 0.79 | KDM4E (0.49) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26701766 | 0.77 | PTGER1 (0.43) | KDM4EALDH1A1SMN1; SMN2MAPK1RXFP1 | |
| SCHEMBL31716266 | 0.75 | KDM4E (0.40) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26611035 | 0.75 | KDM4E (0.48) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26611031 | 0.75 | KDM4E (0.46) | KDM4EPOLBALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023203174-A1 | HETEROCYCLIC CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | PROXYGEN GMBH (AT) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023203174-A1 | HETEROCYCLIC CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | PROXYGEN GMBH (AT) | 2023-10-26 | — | — | WO | disclosed |