Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661179 | 0.80 | MAPT (0.41) | L3MBTL1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL23434798 | 0.74 | MAPT (0.59) | L3MBTL1TDP1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL27720296 | 0.71 | CA1 (0.50) | MAPTRAB9ASMN1; SMN2DPP4NPC1 | |
| SCHEMBL1191400 | 0.70 | MAPT (0.51) | L3MBTL1TDP1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14967316 | 0.70 | MAPT (0.63) | L3MBTL1TDP1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2667033 | 0.70 | CA1 (0.49) | MAPTRAB9ASMN1; SMN2DPP4NPC1 | |
| SCHEMBL16684851 | 0.70 | L3MBTL1 (0.52) | L3MBTL1TDP1MAPTRAB9ATSHR | |
| SCHEMBL14966780 | 0.70 | CA1 (0.52) | TDP1MAPTRAB9ATSHRDPP4 | |
| SCHEMBL1791209 | 0.70 | L3MBTL1 (0.52) | L3MBTL1TDP1MAPTRAB9ATSHR | |
| SCHEMBL5798809 | 0.69 | NPC1 (0.46) | L3MBTL1TDP1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863755-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES | Merck & Co., Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006102067-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES | MERCK & CO., INC. (US) | 2006-09-28 | — | — | WO | disclosed |