Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661178 | 0.80 | L3MBTL1 (0.42) | MAPTSMN1; SMN2LMNADPP4ALDH1A1 | |
| SCHEMBL27720296 | 0.76 | CA1 (0.50) | MAPTSMN1; SMN2DPP4KMT2AALDH1A1 | |
| SCHEMBL2667033 | 0.75 | CA1 (0.49) | MAPTSMN1; SMN2DPP4KMT2AALDH1A1 | |
| SCHEMBL16684851 | 0.70 | L3MBTL1 (0.52) | MAPTKMT2AALDH1A1MEN1LOXL2 | |
| SCHEMBL14966780 | 0.70 | CA1 (0.52) | MAPTDPP4KMT2AALDH1A1GAA | |
| SCHEMBL1791209 | 0.70 | L3MBTL1 (0.52) | MAPTKMT2AALDH1A1MEN1LOXL2 | |
| SCHEMBL22922695 | 0.69 | GRIA4 (0.55) | MAPTKMT2AALDH1A1MEN1LOXL2 | |
| SCHEMBL20622459 | 0.69 | TDP1 (0.67) | MAPTSMN1; SMN2KMT2AALDH1A1GAA | |
| SCHEMBL31614266 | 0.69 | L3MBTL1 (0.49) | MAPTSMN1; SMN2HDAC1KMT2AALDH1A1 | |
| SCHEMBL19940311 | 0.69 | MAPT (0.50) | MAPTDPP4KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863755-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES | Merck & Co., Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006102067-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES | MERCK & CO., INC. (US) | 2006-09-28 | — | — | WO | disclosed |