SCHEMBL26613629

SCHEMBL26613629

Nc1ncnn2c(C3CCN(C(=O)O)CC3)cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12

nearest known ligand 0.89

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ TYRO3 Q06418 20/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26613611 0.96 TYRO3 (0.90) TYRO3
SCHEMBL29626090 0.94 TYRO3 (1.00) TYRO3
SCHEMBL19377682 0.94 TYRO3 (1.00) TYRO3
SCHEMBL19377708 0.93 TYRO3 (1.00) TYRO3
SCHEMBL19377742 0.93 TYRO3 (1.00) TYRO3
SCHEMBL29758802 0.93 TYRO3 (1.00) TYRO3
SCHEMBL19377965 0.92 TYRO3 (0.91) TYRO3
SCHEMBL31051662 0.92 TYRO3 (0.91) TYRO3
SCHEMBL31051666 0.92 TYRO3 (0.91) TYRO3
SCHEMBL29626119 0.92 TYRO3 (0.91) TYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3436461-B1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2023-11-01 — — EP claimed
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