Known targets — ChEMBL curated mechanism
FAURPL10RPL10ARPL11RPL12RPL13RPL13ARPL14RPL15RPL17RPL18RPL18ARPL19RPL21RPL22RPL23RPL23ARPL24RPL26RPL27RPL27ARPL28RPL29RPL3RPL30RPL31RPL32RPL34RPL35RPL35ARPL36RPL36ARPL37RPL37ARPL38RPL39RPL4RPL41RPL5RPL6RPL7RPL7ARPL8RPL9RPL9P7RPL9P8RPL9P9RPLP0RPLP1RPS10RPS11RPS12RPS13RPS14RPS15RPS15ARPS16RPS17RPS18RPS19RPS2RPS20RPS21RPS23RPS24RPS25RPS26RPS27RPS27ARPS28RPS29RPS3RPS3ARPS4XRPS4Y1RPS5RPS6RPS7RPS8RPS9RPSA
The experimentally established mechanism targets of Cycloheximide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 10/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | NR2F2 | P24468 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | FKBP4 | Q02790 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | SLC2A1 | P11166 | 1/20 | 1.00 |
| ▸ | EIF4A1 | P60842 | 1/20 | 1.00 |
| ▸ | EPAS1 | Q99814 | 1/20 | 1.00 |
| ▸ | FKBP14 | Q9NWM8 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cycloheximide SCHEMBL30020292 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL1714687 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL3764340 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Naramycin B SCHEMBL29356383 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL1753509 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL17223570 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL24914327 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL9344504 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL674135 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA | |
| Cycloheximide SCHEMBL3764335 | 1.00 | FKBP1A (1.00) | FKBP1ASMN1; SMN2NR2F2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 41894 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| US-12630885-B2 | Viability detection and quantification assay of waterborne pathogens by enrichment | PHIGENICS, LLC | 2026-05-19 | — | — | US | claimed |
| CN-122025251-A | Special power cable suitable for high-altitude severe environment and preparation method thereof | 航天瑞奇电缆有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4058037-B1 | FIBROBLAST-BASED THERAPY FOR TREATMENT AND PREVENTION OF STROKE | SPINALCYTE LLC (US) | 2026-01-28 | — | — | EP | claimed |
| EP-4673458-A1 | METHODS OF ENHANCING PRODUCTION OF METABOLITES IN BACTERIA | JOHN INNES CENTRE (GB) | 2026-01-07 | — | — | EP | claimed |
| US-20250367182-A1 | METHOD FOR INDUCING IN-SITU REGENERATION OF MAMMAL AND USE THEREOF | INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2025-12-04 | — | — | US | claimed |
| US-20250367183-A1 | SUBSTANCE FOR PROMOTING REGENERATION AND REPAIR OF ORGANS OF MAMMALS AND USE THEREOF | INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2025-12-04 | — | — | US | claimed |
| EP-3060043-B1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | CORTEVA AGRISCIENCE LLC (US) | 2025-11-26 | — | — | EP | claimed |
| US-20250353919-A1 | Antibodies Against TL1A and Uses Thereof | TEVA PHARMACEUTICALS AUSTRALIA PTY LTD (AU) | 2025-11-20 | — | — | US | claimed |
| EP-3578542-B1 | COMPOSITIONS HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO | CORTEVA AGRISCIENCE LLC (US) | 2025-11-12 | — | — | EP | claimed |
| US-4425737-A | USING ALPHA-AMYLASE TO IDENTIFY EMBRYO CONTAINING SEED SEGMENTS | AGRIGENETICS RESEARCH ASSOCIATES LIMITED (US) | 1984-01-17 | — | — | US | claimed |
| US-4307193-A | PROPAGATING FROM TISSUE CELLS | TORAY INDUSTRIES, INC. (JP) | 1981-12-22 | — | — | US | claimed |
| EP-0041029-A1 | Process and compositions for in vitro diagnosis of diseases due to lysozomial deficiencies, chromosomal aberrations, muscular dystrophy or cystic fibrosis | INSTITUT PASTEUR (FR) | 1981-12-02 | — | — | EP | claimed |
| US-4299726-A | Process for preparing whole blood reference controls having long term stability, preconditioning diluent and media therefor | COULTER ELECTRONICS, INC. (US) | 1981-11-10 | — | — | US | claimed |
| US-4297339-A | COMPRISING AN EMULSIFIER AND OXIDIZED WAX; AGRICULTURE; COATINGS | THE UPJOHN COMPANY (US) | 1981-10-27 | — | — | US | claimed |
| US-4292408-A | Mass and a method of preparing same of living cells of organisms for adsorbing metal ions from a physiological solution, and employment of the mass for enriching metals | KERNFORSCHUNGSANLAGE JULICH GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-29 | — | — | US | claimed |
| US-4145209-A | CYCLOHEXIMIDE AND GLYOXAL DIOXIME | DIAMOND SHAMROCK CORPORATION (US) | 1979-03-20 | — | — | US | claimed |
| US-4107300-A | SULFUR CONTAINING COMPOUNDS, CALCIUM CHLORIDE | SANKYO COMPANY LIMITED (JP) | 1978-08-15 | — | — | US | claimed |
| US-4073637-A | Cycloheximide-imide or carbamate combinations as fruit abscission agents | DIAMOND SHAMROCK CORPORATION (US) | 1978-02-14 | — | — | US | claimed |
| US-3970443-A | TETRACHLOROISOPHTHALONITRILE | DIAMOND SHAMROCK CORPORATION (US) | 1976-07-20 | — | — | US | claimed |