Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4550434 | 0.89 | CYP3A4 (0.40) | SMN1; SMN2ALDH1A1CYP2C19CYP2D6USP2 | |
| SCHEMBL12045659 | 0.88 | CYP1A2 (0.43) | SMN1; SMN2ALDH1A1CYP2C19MAPK1CYP2D6 | |
| SCHEMBL16907554 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CYP2C19MAPK1CYP2D6 | |
| SCHEMBL24597263 | 0.82 | CYP2D6 (0.42) | ALDH1A1CYP2C19MAPK1CYP2D6USP2 | |
| SCHEMBL26807125 | 0.81 | HSD11B1 (0.39) | SMN1; SMN2ALDH1A1CYP2C19MAPK1CYP2D6 | |
| SCHEMBL28996354 | 0.79 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1CYP2C19MAPK1CYP2D6 | |
| SCHEMBL26806869 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1CYP2C19MAPK1CYP2D6 | |
| SCHEMBL24723402 | 0.78 | HSD11B1 (0.33) | CYP2D6USP2CYP1A2CYP2C9 | |
| SCHEMBL20228010 | 0.77 | USP2 (0.45) | SMN1; SMN2ALDH1A1USP2EPHX2 | |
| SCHEMBL4815629 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1CYP2C19MAPK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365605-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-11-16 | — | — | US | disclosed |
| US-20230339902-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339902-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | IKZF1, IKZF3, IKZF2 | SMN1; SMN2 1860/4885ALDH1A1 4344/4885CYP2C19 4619/4885 |
| US-20230365605-A1 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | SMN1; SMN2 432/4885ALDH1A1 3594/4885CYP2C19 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.