⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17196465 | 0.84 | — | — | |
| SCHEMBL20269577 | 0.80 | — | — | |
| SCHEMBL29742695 | 0.80 | — | — | |
| SCHEMBL1893972 | 0.77 | — | — | |
| SCHEMBL32667294 | 0.77 | RIPK1 (0.34) | — | |
| SCHEMBL20552967 | 0.77 | BCHE (0.32) | — | |
| SCHEMBL26620313 | 0.75 | CSNK2A1 (0.32) | — | |
| SCHEMBL30365630 | 0.74 | PDE2A (0.30) | — | |
| SCHEMBL26686758 | 0.74 | CSNK2A1 (0.37) | — | |
| SCHEMBL30756162 | 0.72 | SIGMAR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250346576-A1 | KCNT1 INHIBITORS COMPRISING A PYRAZOLE CORE AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2025-11-13 | — | — | US | disclosed |
| EP-4514779-A1 | KCNT1 INHIBITORS COMPRISING A PYRAZOLE CORE AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| CN-119317619-A | KCNT1 inhibitors comprising pyrazole cores and methods of use | 普拉西斯精密医药公司 | 2025-01-14 | — | — | CN | disclosed |
| WO-2023211853-A1 | KCNT1 INHIBITORS COMPRISING A PYRAZOLE CORE AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023211853-A1 | KCNT1 INHIBITORS COMPRISING A PYRAZOLE CORE AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-11-02 | — | — | WO | disclosed |