Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 2/20 | 0.56 |
| ▸ | CCNK | O75909 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCND2 | P30279 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30670372 | 0.85 | SYK (0.52) | CDK2ALKBRD4SYKBTK | |
| SCHEMBL30670379 | 0.82 | ALK (0.54) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619892 | 0.82 | ALK (0.54) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619987 | 0.82 | CCND3 (0.59) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619844 | 0.79 | CCND3 (0.56) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26620009 | 0.79 | CCND3 (0.58) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619860 | 0.77 | CCND3 (0.49) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL26619881 | 0.75 | ALK (0.49) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL30670362 | 0.75 | ALK (0.49) | CCND3CCNKCCNA2CDK2CDK9 | |
| SCHEMBL5104977 | 0.75 | ALK (0.64) | CCND3CCNKCCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213211-A9 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2024-03-21 | — | — | WO | disclosed |
| WO-2023213211-A1 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2023-11-09 | — | — | WO | disclosed |
| CN-116514779-A | 2, 4-disubstituted-5-fluoropyrimidine derivative and preparation method and application thereof | 中南大学 | 2023-08-01 | — | — | CN | disclosed |