Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 6/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | FES | P07332 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620641 | 0.85 | CCND3 (0.56) | SYKEGFRBRD4FLT3BTK | |
| SCHEMBL2968000 | 0.70 | EGFR (0.61) | EGFRAURKAALKJAK2INSR | |
| SCHEMBL657421 | 0.69 | SYK (1.00) | SYKEGFRFLT3BTKAURKA | |
| SCHEMBL31684789 | 0.69 | SYK (0.71) | SYKEGFRBRD4FLT3BTK | |
| SCHEMBL655906 | 0.69 | SYK (0.65) | SYKEGFRBRD4FLT3BTK | |
| SCHEMBL30515505 | 0.68 | SYK (0.57) | SYKEGFRBRD4FLT3BTK | |
| SCHEMBL26619987 | 0.67 | CCND3 (0.59) | SYKBRD4FLT3BTKALK | |
| SCHEMBL26394684 | 0.67 | EGFR (0.79) | SYKEGFRBRD4FLT3BTK | |
| SCHEMBL29793826 | 0.67 | EGFR (0.79) | SYKEGFRBRD4FLT3BTK | |
| SCHEMBL15652893 | 0.67 | JAK2 (0.45) | SYKJAK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213211-A9 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2024-03-21 | — | — | WO | disclosed |
| WO-2023213211-A1 | 2,4-DISUBSTITUTED-5-FLUOROPYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND USE THEREOF | 长沙晶易医药科技股份有限公司 | 2023-11-09 | — | — | WO | disclosed |