Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31081197 | 0.87 | MAPT (0.46) | PTPN2KDM4ETSHRHSD17B10JAK2 | |
| SCHEMBL828767 | 0.85 | CSNK2A2 (0.44) | PTPN2KDM4EHSD17B10HDAC3HDAC4 | |
| SCHEMBL26621990 | 0.85 | MAPT (0.50) | PTPN2KDM4ETSHRHSD17B10JAK2 | |
| SCHEMBL32672220 | 0.83 | MAPK14 (0.45) | PTPN2KDM4ETSHRHSD17B10JAK2 | |
| SCHEMBL18069891 | 0.83 | PTPN2 (0.48) | PTPN2KDM4ETSHRHSD17B10JAK2 | |
| SCHEMBL3822544 | 0.81 | ICAM1 (0.41) | PTPN2KDM4EHSD17B10HDAC3HDAC4 | |
| SCHEMBL21505451 | 0.80 | KDM4E (0.46) | KDM4EHDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL30640499 | 0.80 | KDM4E (0.46) | KDM4EHDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL17080891 | 0.80 | SLC9A1 (0.53) | PTPN2KDM4ETSHRHSD17B10JAK2 | |
| SCHEMBL9612657 | 0.79 | SLC9A1 (0.56) | KDM4ETSHRHSD17B10JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023214325-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AND USES THEREOF AS TET2 INHIBITORS | NOVARTIS AG (CH) | 2023-11-09 | — | — | WO | disclosed |