Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | CEL | P19835 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28688565 | 0.83 | PARP1 (0.45) | MAOAMAOBPARP1KDM4EALDH1A1 | |
| SCHEMBL2653820 | 0.81 | KDM4E (0.42) | MAOAMAOBPARP1KDM4EALDH1A1 | |
| SCHEMBL14775706 | 0.72 | PARP1 (0.44) | MAOAMAOBPARP1KDM4EALDH1A1 | |
| SCHEMBL30973807 | 0.70 | KDM4E (0.50) | MAOAPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL3581495 | 0.70 | KDM4E (0.50) | MAOAPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL2951374 | 0.70 | PARP1 (0.53) | MAOAMAOBPARP1KDM4EALDH1A1 | |
| SCHEMBL4959318 | 0.69 | PTPN5 (0.46) | FEN1KDM4EPTPN5PTPN2CEL | |
| SCHEMBL4960398 | 0.69 | PTPN5 (0.46) | FEN1KDM4EPTPN5PTPN2CEL | |
| SCHEMBL4958862 | 0.69 | PTPN5 (0.46) | FEN1KDM4EPTPN5PTPN2CEL | |
| SCHEMBL4958978 | 0.69 | PTPN5 (0.46) | FEN1KDM4EPTPN5PTPN2CEL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904466-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006760-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |