Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP5 | P51878 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26624526 | 0.89 | PRMT1 (0.43) | ALDH1A1SMN1; SMN2NAPEPLDTMEM97SIGMAR1 | |
| SCHEMBL23702506 | 0.85 | NAPEPLD (0.50) | SMN1; SMN2MAPTGRM5NAPEPLDTMEM97 | |
| SCHEMBL26625339 | 0.80 | NAPEPLD (0.35) | CASP1MAPTGRM5NAPEPLDCYP1A2 | |
| SCHEMBL22402422 | 0.78 | VEGFA (0.54) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C9 | |
| SCHEMBL24251635 | 0.77 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL26620439 | 0.77 | NAPEPLD (0.51) | SMN1; SMN2MAPTGRM5NAPEPLDPIK3CB | |
| SCHEMBL5174004 | 0.76 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL3569051 | 0.75 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2HRH3CYP1A2CYP2C9 | |
| SCHEMBL25001507 | 0.75 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HRH3CYP1A2CYP2C9 | |
| SCHEMBL23702477 | 0.74 | NAPEPLD (0.53) | ALDH1A1SMN1; SMN2MAPTNAPEPLDTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339910-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339910-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | KRAS, NRAS, HRAS | ALDH1A1 3682/4885SMN1; SMN2 4027/4885CASP1 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.